I called to doctors office today to tell them that that I received the Lupron Depot and hoped that I would be scheduling my appointment to have that administered in the next couple weeks. In the mean time I asked if my results were in and she said no, but then put me on hold to schedule the Lupron shot and then told me that my results had in fact come in and that they were "positive". My initial thought was that "positive" meant that I tested "positive" for the Beta-3 Integrin a protein that is said to be one of the key proteins for adhesion of embryos, but her response was now we know what the problem is...
So I continued to say, "so I don't have the protein" and she said "no, and the problem is, is that the protocol for this particular protein is a 3 month prep, meaning no IVF until July"... my heart immediately sank. I would have to take an oral protocol for the next 3 months in order to introduce this missing protein into my system. Needless to say, I ended the conversation with her a bit confused; why did she use the word "positive" and why have I had implantation before if I don't have the protein? These are clearly 2 questions for my doctor and luckily I have an appointment this Wednesday at 9am to hopefully get some of these answers. But thanks to Dr. Google, here is what I've found so far:
Failure to express this protein appropriately has been theorized to be a cause of unexplained implantation failure. Why some women do not produce beta-3 integrins is usually unknown. However, some proposed causes include presence of blocked fallopian tubes filled with inflammatory fluid, endometriosis, and poor progesterone production. {via}
As you can read, what this is basically saying is that lack of this protein can be the cause of unexplained implantation failure (could be why all 3 of my IVF cycles failed) and a proposed cause is enodmetriosis (what I have been diagnosed with, Stage II). I don't have blocked tubes and I don't have poor progesterone production so I am assuming that my endo the probable cause to this deficiency. From what I'm reading online, the 3 month prep will be Letrozole possibly followed by another biopsy. This of course is another question for my doctor on Wednesday, but you bet your ass I'll be researching as much as possible the next couple days.
All I can seem to do is remind myself, once again, of my own advice... this process takes time. I'm not sure why I'm having such a hard time grasping that. Maybe it's because we've been on such a long break and I know I am so ready to move forward. I am happy that we are ruling things out and doing more testing, but at the same time I have to wonder, why when I brought this up to my other doctor did he not seem concerned? Why have I had implantation before? Why can't I seem to catch a break when it comes to infertility treatment?
I know that we are all more than familiar with the hurdles, the set backs, and the let downs that come with infertility treatment. We are always waiting for something. For a cyst to go away, for AF to show, for two weeks to pass, for a blood work to be done. It's nothing but a waiting game and it really is exhausting. I can tell myself, oh well, July will be better because I'll be pretty settled into the house and I can enjoy summer and we can take some bike trips, and yada yada about trying to make it make perfect sense as to why waiting another 3 months is for the best, but honestly there is never going to be a perfect time and the longer I have to wait, the more it seems so far out of reach and the more time I have to question if this is ever going to be possible for us.
I continually have to remind myself that this isn't a race, it's not a game, there isn't a deadline, I'm not in competition with anyone, etc. etc. I am just so ready for this to just happen for us. As discouraged as I am right now, I am happy that we could have possibly found a reason to our issues, but I am also sick of jumping hurdles. I know that this path isn't straight and narrow for anyone. Even those who get their BFP on their first cycle still have to endure things not working out as they want them. As a person who appreciates a plan, a person with little patience, a person who craves instant gratification, a person who has wanted this for 3 and a 1/2 years, I hate that I have no control over this.
I guess I'll find out more on Wednesday and be sure to update.